Peptide Chemistry
Peptide Chemistry Overview
Peptide chemistry focuses on the design, synthesis, and modification of peptides—short amino acid chains with crucial biological functions. Using techniques like solid-phase peptide synthesis (SPPS), unnatural amino acid incorporation, and cyclization, researchers enhance peptide stability, bioavailability, and resistance to degradation.
This field enables the development of linear, cyclic, and constrained peptides for use in oncology, infectious diseases, and metabolic disorders. As interest in biologics and precision medicine grows, peptide chemistry remains central to modern drug discovery and development.
● Advanced Peptide Chemistry (Linear, Cyclic, Stapled, Unnatural AAs)
Advanced peptide chemistry designs functionally enhanced peptides for therapeutic use. Cyclic and stapled peptides offer improved stability, permeability, and target engagement. Incorporating unnatural amino acids boosts activity, specificity, and metabolic stability, enabling next-gen drugs for cancer, metabolic, and infectious diseases.
● PEGylation, Lipidation, Custom Libraries
PEGylation enhances therapeutic peptides and proteins by attaching polyethylene glycol chains to improve solubility, stability, half-life, and reduce immunogenicity. Lipidation adds lipid groups to boost membrane permeability, bioavailability, and targeted delivery, aiding in long-acting formulations. Custom libraries are tailored collections of compounds designed for high-throughput screening and SAR studies, accelerating lead discovery in drug development.
● Peptide Mapping & Sequencing:
Peptide mapping breaks down proteins into smaller peptides for sequence analysis, helping verify protein identity and structure. Peptide sequencing, often via mass spectrometry, determines the precise amino acid order and detects post-translational modifications. These techniques are essential for characterizing recombinant proteins and ensuring quality and consistency in biologics.